Nippon Ronen Igakkai Zasshi. Japanese Journal of Geriatrics
Print ISSN : 0300-9173
Comparison of Clinical Usefulness of β-blocker in Aged and Younger Essential Hypertension
Double Blind Trial Using Bunitrolol
Kizuku KuramotoMasao IkedaKikuo ArakawaYoshiaki InagakiYoshihiro KanekoYoshiaki MasuyamaNoboru YamazakiMasayuki Tsuchiya
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1984 Volume 21 Issue 1 Pages 20-26

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Abstract

Effects of β-blocker, bunitrolol, on essential hypertension were evaluated comparatively in two different age groups. They were divided in patients of 60 years or older and those of 59 years or younger. The study was carried out with 66 cases in monotherapy (aged patients: 23 cases of 63.8 years on an average, younger patients: 43 cases of 49.9 years) and with 61 cases in combined therapy (aged patients: 28 cases of 66.2 years, younger patients: 33 cases of 49.8 years) according to double blind method.
Hypotensive effects (blood pressure fall by 20/10mmHg or more) were observed in 73.9% of the aged patients and 62.8% of the younger patients on monotherapy, and 71.4% of the aged patients and 66.7% of the younger patients on combined therapy, respectively. There was no statistically significant difference in the rates of efficacy between the two age groups of patients on either therapy.
The incidence of side effects was 8.7% in the aged patients and 7.0% in the younger patients on monotherapy, while the incidence for combined therapy was 14.3% and 15.2% respectively. There was no significant difference in the incidence between the two age groups of patients on either therapy.
The results indicated bunitrolol to have its usefulness (“useful” or above) at 78.3% in the aged patients and 69.8% in the younger patients on monotherapy, while the rates in the patients on combined therapy were 75.0% and 60.6% respectively. There was also no significant difference between the two age groups on either therapy. Beta blocker bunitrolol was thus esteemed to be equally useful for the treatment of both aged and younger patients with essential hypertension.

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© The Japan Geriatrics Society
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