Abstract
The response of lymphocytes from healthy controls (N=28, 41-67 years, female) and Alzheimer's disease patients (N=11, 50-64 years, female) to phytohemagglutinin (PHA-P) has been measured according to MTT-assay, by which the activities of dehydrogenases in mitochondria could be estimated. A linear age-related decrease in reactivity to PHA-P was found both for healthy controls (r=-0.496, α<0.01), and for Alzheimer's disease patients (r=-0.603, α<0.05). The regression equations are:
Y=-0.0146X+1.461 (healthy controls)
Y=-0.0150X+1.437 (Alzheimer's disease patients)
where, X and Y designate the age of individuals and absorbance, respectively.
