Abstract
In 66 aged patients, with normal serum creatinine level (≤1.2mg/dl) and having underlying disease, the measured creatinine clearance (Ccr) value was compared with the predicted Ccr value. The best correlation was obtained by the formulae of Yasuda. In each group of bed-ridden patients, severe infection, and parenteral alimentation patients, the measured Ccr value was lowered about 80% in comparison with the predicted Ccr value. The simultaneously measured urinary 3-methylhistidine was also lowered. This estimated serum creatinine level tended to understimate renal insufficiency when accompanied by decreasing systemic muscle volume.
