Hematocrit, Serum Lipids and Cardiovascular Indices as Risk Factors in Vascular Dementia

Abstract

Multiple cerebro-cardio vascular risk factors were examined in 24 patients (mean age: 73±11 years) with multi-infarct dementia (MID) (De (+) group) and 27 patients (mean age: 74±9 years) with multiple cerebral infarcts without dementia (De (-) group). All patients in the De (+) group had a score of 10 or less on Hasegawa's index or Mini-Mental State, and those in the De (+) group had a score of 22 or more. There was no difference between the two groups in terms of hematocrit, serum BUN, creatinine, uric acid, P_O2, ejection fraction on echocardiography, the incidence of atrial fibrillation, diabetes mellitus or ischemic heart disease. Total cholesterol was lower and the atherogenic index was higher in the De (+) group (p<0.1). There was no difference in history of hypertension between the two groups. However, casual systolic blood pressure and ambulatory mean daily systolic blood pressure (S-AMBP) were significantly lower in the De (+) group than the De (-) group (p<0.01 and p<0.05, respectively). The standard deviation of S-AMBP (S-AMBP-SD) was also significantly lower in the De (+) group than the De (-) group. The treatment and the optimal control range of hypertension of the elderly with multiple cerebral infarcts still remains controversial.