1992 Volume 29 Issue 11 Pages 881-887
The phermacokinetics of oral Alminoprofen, a nonsteroidal anti-inflammatory drug, were studied in five elderly patients with rheumatoid arthritis and spondylosis deformans after 200mg (three times a day) repeated dose for 5 days. The pharmacokinetic parameters after oral administration of Alminoprofen were analyzed by the one-compartment open model method. The maximum plasma concentrations (Cmax) were 16.1 ±2.5μg/ml, after dosing on day 1, 25.2±1.6μg/ml on day 3 and 21.6±2.7μg/ml on day 5. The maximum time (Tmax) were about 2 hours after the medication in al cases. The area under the curve in drug concentration in plasma versus time (AUC) were 58.5±6.3μg hr/ml on day 1, 58.5±3.1μg hr/ml on day 3 and 58.1±8.5μg hr/ml on day 5. The biological half-lives (t1/2) were 2.45± 0.35, 2.09±0.82 and 2.49±0.63 hours, after dosing on day 1, day 3 and day 5, respectively. The analysis of moment in pharmacokinetics revealed that the mean residence time (MRT) on day 1, day 3 and day 5 observed were 2.31±0.03, 2.15±0.09 and 2.15±0.07 hours, respectively. The variance residence times (VRT) observed were 0.95±0.05hour2 on day 1, 0.88±0.09hour2 on day 3 and 1.06±0.07hour2 on day 5. The ratios of accumulation calculated were 1.16±0.05 in both the morning medication on day 3 day 5, and it therefore appears that the steady-state equilibrium is established within 3 days after commencement of dosage. The result suggest that Alminoprofen has none or almost no accumulation effect in elderly as well as adult patients.
