Abstract
Three hypercholesterolemic patients (Type 3) were subjected to receive carbohydrate rich diet (as sucrose or starch) for the purpose of analyzing the effect of the kinds of carbohydrate on the plasma lipids. During the cource in which patients were administered with sucrose rich diet, triglyceride concentration in the plasma increased more remarkably, and palmitic acid as well as oleic acid which can be both synthesized in the body increased, and linoleic acid decreased.
Dogs' experiments were carried out to evaluate whether glucose or fructose which can be split from either starch or sucrose would be responsible for the increase of plasma lipids. The group administered with fructose rich diet showed higher triglyceride concentration in the plasma and in the liver. This group also showed the increased palmitic and oleic acid, and decreased linoleic acid in the triglyceride fraction of the liver.
These results indicate that fructose might be more responsible than glucose for the increment of the plasma lipids by way of converting itself into lipids.
