1970 Volume 7 Issue 5 Pages 302-312
The prophylactic effects of thyrocalcitonin, high cholesterol diet and conjugated estrogen on the Na-Sulfacetylthiazole (SAT)-induced cardiovascular changes were studied in rats. (i) Effect of thyrocalcitonin: Daily subcutaneous injection of 200 MRC mU of thyro calcitonin dissolved in 16% gelatin prevented the increase in the calcium content of the heart after SAT treatment, but not prevented histological changes and 24hrs. 45Ca uptake. (ii) Effect of feeding with high cholesterol diet: Feeding adult rats with high cholesterol diet for 4 weeks prior to the administration of SAT and thereafter untill the day of sacrifice prevented the histological changes and abnormal calcium metabolism in the aorta and heart but not in the kidneys. The 24 hrs. uptake of 45Ca by the femur was markedly decreased through feeding with high cholesterol diet as compared with control animals. Serum total cholesterol was markedly elevated. (iii) Effect of conjugated estrogen: Daily subcutaneous injection of 100r/100g body weight of conjugated eatrogen in rats failed to prevent the SAT-induced cardiovascular changes and increased the 24hrs, uptake of 45Ca by the heart and kidneys. Serum 45Ca was also increased. (iv) Effect of the cholesterol feeding and conjugated estrogen: SAT-induced cardiovascular changes and abnormal calcium metabolism were prevented in the aorta and heart but not in the kidneys by such treatment. The 24hrs. uptake of 45Ca by the fumer was markedy decreased through such treatment as compared with control animals.
