MANIFESTATION OF ABNORMALITIES IN ABNORMAL INTRAUTERINE ENVIRONMENT

III. MALDEVELOPMENT OF THE CENTRAL NERVOUS SYSTEM, EYE, AND MANIFESTATION OF HEART ABNORMALITIES

Abstract

1. More than thirty pregnant mice were administered with a single intravenous injection of 1cc, of 1 per cent trypan blue aqueous solution on their 6th, 7th, 8th, and 9th day of pregnancy and from them thirty mothers were selected, whose embryos were examined and their prognoses were clear. Almost all embryos were examined on their 13th embryonic day.
2. Normal embryos and retarded embryos without abnormalities were manifested most in D group, next in the C group, and least frequently in the G group. That is, the earlier administered, the fewer embryos without abnormalities were manitested.
3. More abortions were also observed in the F and G group than in the D and C group.
4. More abnormalities found to be alive on the 13th day of pregnancy were manifested in C group administered on the 8th day of pregnancy than in other groups. In group E administered on the same day of pregnancy, fewer abnormal embryos were found than in group C. However, in group E, more various kinds of gross abnormalities were manifested than in other groups. Therefore a certain racial difference seems to be present.
5. In general, central nerve abnormalities were manifested in various conditions in each group. They seem to result from the process of hyperplasia or mal-closure of the medullary tube.
6. Abnormal embryos with seriously malformed central nervous system were usually found dead on the 10th-12th day of pregnancy. The head formation in these cases were small and often associated with enlarged pericardium. More of the secases were found in group F than in the other groups.
7. Marked abnormalities except those of the central nervous system were as follows: malformed eyecup, anophthalmos, median harelip associated with pseudencephaly, dextrocardia, ectopia cordis and other abnormal conditions of the heart anlage, taillessness and blister formation etc..