A chromosome study in five near-diploid human tumors

Abstract

In present study the chromosomes of tumor cells were investigated in human tumors, with particular reference to the number and morphology of chromosomes. The type of tumors under study are shown in Table 1. The results of the chromosome investigation have revealed that every of these five tumors is characterized by near-diploid tumor cells.
The following four tumors, Nos. 26, 32, 40 and 46, are provided with stem-cells having the chromosome number mode at 46 or 48.
The uterine carcinoma (No. 30) here studied contains at least two distinct stemlines, consisting of a cell-line of near-diploid chromosomes (48 in number) and that of hyperdiploid chromosomes (55 in number).
The chromosome constitutions of the tumor stem-cells of five tumors here considered show a general likeness to the normal somatic complex, so far as they were compared with the human complex reported by Tjio and Levan (1956).