Abstract
Physiological properties of two classes of arginine sensitive mutants in Salmonella typhimurium were examined. The growth of ars mutant cells was inhibited specifically by arginine and that of aus mutant cells by either arginine or uracil. Uracil removed the inhibition caused by arginine in both mutants and arginine removed the inhibiton caused by uracil in aus mutant cells. The direct effect of these mutations is assumed to inhibit biosynthesis of carbamyl phosphate in the presence of arginine or uracil. The growth inhibition by arginine was more critical at higher incubation temperatures.
