A new allele of the tottering locus, rolling mouse Nagoya, on chromosome no. 8 in the mouse

Abstract

Mating experiments showed that the rolling gene, rol, causing abnormal locomotor activity was an allele of the tottering, tg, locus and that this locus was closely linked to the non-specific esterase-1 locus on chromosome no. 8. As a consequence, it is demonstrated that the tg locus has three mutant alleles; tottering, tg, leaner, la, and rolling, rol. The mice with genotype rol/tg show clinical symptoms similar to rol/rol rather than to tg/tg. The symptom of ataxia occurs at about two weeks of age in this mutant, which survives to the adult age.