Genome Informatics
Online ISSN : 2185-842X
Print ISSN : 0919-9454
ISSN-L : 0919-9454
DOCKING-CALCULATION-BASED METHOD FOR PREDICTING PROTEIN-RNA INTERACTIONS
MASAHITO OHUEYURI MATSUZAKIYUTAKA AKIYAMA
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JOURNALS FREE ACCESS

2011 Volume 25 Issue 1 Pages 25-39

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Abstract

Elucidating protein-RNA interactions (PRIs) is important for understanding many cellular systems. We developed a PRI prediction method by using a rigid-body protein-RNA docking calculation with tertiary structure data. We evaluated this method by using 78 protein-RNA complex structures from the Protein Data Bank. We predicted the interactions for pairs in 78×78 combinations. Of these, 78 original complexes were defined as positive pairs, and the other 6,006 complexes were defined as negative pairs; then an F-measure value of 0.465 was obtained with our prediction system.

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© 2011 Japanese Society for Bioinformatics
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