Genome Informatics
Online ISSN : 2185-842X
Print ISSN : 0919-9454
Comprehensive Analysis and Prediction of Synthetic Lethality Using Subcellular Locations
Takuji YamadaShuichi KawashimaHiroshi MamitsukaSusumu GotoMinoru Kanehisa
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2005 Volume 16 Issue 1 Pages 150-158


The lethality of a gene is a fundamental and representative measure for understanding the function of a gene and its associated biosystems. Recently, many research groups have started focusing on the concept of synthetic lethality. The synthetic lethality between genes is defined by the combination of mutations in two genes causing cell death. Here, we confirm that synthetic lethality and cellular location have close relationships among the Saccharomyces cerevisiae genes. Furthermore, we attempt the prediction of candidate gene pairs with synthetic lethality. The prediction is based on the hierarchical aspect model (HAM) which learns from a data set of cellular location to estimate a likelihood value indicating the synthetic lethality between genes.

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