Genome Informatics
Online ISSN : 2185-842X
Print ISSN : 0919-9454
ISSN-L : 0919-9454
A FRAMEWORK FOR DETERMINING OUTLYING MICROARRAY EXPERIMENTS
RAYMOND WANÅSA M. WHEELOCKHIROSHI MAMITSUKA
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JOURNAL FREE ACCESS

2008 Volume 20 Pages 64-76

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Abstract
Microarrays are high-throughput technologies whose data are known to be noisy. In this work, we propose a graph-based method which first identifies the extent to which a singlemicroarray experiment is noisy and then applies an error function to clean individual expression levels. These two steps are unified within a framework based on a graph representation of a separate data set from some repository. We demonstrate the utility of our method by comparing our results against statistical methods by applying both techniques to simulated microarray data. Our results are encouraging and indicate one potential use of microarray data from past experiments.
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© Japanese Society for Bioinformatics
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