2016 Volume 40 Issue 2 Pages 123-130
The effects of aerobic exercise, low-intensity resistance training (3 sets of 10 repetitions at 20RM: repetition maximum), and high-intensity resistance training (3 sets of 10 repetitions at 10RM) on the serum uric acid level of 3 healthy control subjects and 6 hyperuricemic subjects were examined. Aerobic exercise did not significantly change the serum uric acid levels of either subject groups. However, a significant increase of the serum uric acid level was observed in hyperuricemic subjects with low and high-intensity resistance training on the next day. Also, a significant increase of the serum uric acid level was observed in those subjects immediately after the high-intensity resistance training. Resistance training mainly strengthens fast-twitch muscles that show anaerobic metabolism depending on the glycolytic system. Therefore, there is a possibility that the inhibited excretion of uric acid in urine by lactate derived from muscle contraction increased the serum uric acid level immediately after resistance training. Also, there was no significant difference, but an increased serum CK level in both healthy and hyperuricemic subjects was observed on the next day. One of the possibilities that degradation of purine ribonucleotides leaked from muscle subjected to mechanical stress affects the increased serum uric acid level. There is a possibility that resistance training increases serum uric acid depending on the exercise intensity, and further research on the mechanism is needed. It was reported that resistance training is effective for the prevention of lifestyle-related disease through improved insulin sensitivity, elevated serum HDL cholesterol level, increased muscle mass, and accelerated basal metabolic rate. For patients with gout or hyperuricemia, the combination of aerobic exercise and reasonably low-intensity resistance training is recommended while checking whether they have a history of gouty arthritis and monitoring their uric acid level.
