2017 Volume 41 Issue 1 Pages 7-13
There are many uncertainties regarding the serum uric acid level in children, including the normal range, because of their growth period. Metabolic diseases are common in cases showing high values, but these cases show the low frequency. It is known that in general clinical data, the age distribution of the serum uric acid level is bimodal. The peak of young children under 5 years old involved infectious diseases, including viral gastroenteritis.
In our hospital, serum uric acid samples from children were measured at relatively more frequently (65% of the serum creatinine sample number) than in other patient groups. High-level samples showing 7.0 mg / dL or more numbered 28 samples from 575 uric acid samples in a 9-month period.
The backgrounds of the 28 patients providing the samples were examined. Acute gastroenteritis was found in 17 cases, including 8 rotaviruses, followed by 5 cases of autointoxication and 3 cases of upper respiratory tract infection. There was no correlation between the urea nitrogen value / creatinine value ratio (BUN / Cr) and serum uric acid value of these 28 patients' samples.
In recent years, the intestinal excretion pathway of uric acid has been drawing attention, and it will be necessary to study the relation between gastroenteritis and hyperuricemia in children in the future. For further investigation, clinicians should pay more attention to hyperuricemia in children.
