Abstract
A 55 - year - old man was admitted to the hospital because of pulmonary emphysema and benign prostatic hypertrophy. During the administration of chlormadinone acetate (50mg per day ), serum uric acid level was decreased from 4.0mg/dl to 1.9mg/dl and fractional uric acid clearance was high, but daily urinary excretion of uric acid was within normal range. In addition, probenecid loading test showed an increase in fractional uric acid clearance from 16.6% to 61.5% and pyrazinamide suppression test showed a marked decrease in fractional uric acid clearance to 2.3%. Serum uric acid level returned to normal after the cessation of chlormadinone acetate. These results suggest that the cause of hypouricemia is renal origin and chlormadinone acetate acts on the site of tubular secretion in the renal handling of uric acid.
