Abstract
The analysis of familial ag g r e gation was carried out on the residents in Tooshi island, Mie prefecture, closed community in which outdoor environmental factors are expected to be uniform. The standardized serum uric acid value called “normal quotient” of serum uric acid value were used for the sake of comparative study. This study suggests that gene action may be caused by so called polygene system. In addition to polygenic inheritance, the value of serum uric acid is also influenced by the interaction of genetic and environmental factors. In the parent-chi l d r en analysis, the most consistent relationship was. found in mother and child. There was no significant aggregation of serum uric acid values between spouses, although there was very significant aggregation between siblings. The extent of aggregation of serum uric acid values between siblings was not significantly different from that of mother and child. Consequently, our present study lends further weight to the view that serum uric acid values are influenced mainly by mothers' genetic factors.
