Abstract
The renal clearance studies and pyrazinamide (PZA) suppression tests were performed in uncomplicated diabetics.1) The uric acid clearance (Cua) in diabetics was higher than that in normal subjects. The higher blood glucose was, the higher Cua was trend to be. Significant positive correlations between FBS and Cua or Cua/Ccr ratio were found. The Cua decreased as blood sugar reduced to normal range by treatment. Urinary uric acid (Uua) excretion increased when urine sugar increased in volume.
2) A significant negative correlation between Cua and SUA, and significant positive correlation between Cua and Uua were found.
3) After PZA administration, SUA was unchanged, but Cua, Cua/Ccr ratio were markedly reduced. Reabsorption rate of urate in the tubule and secretion rate were higher and lower in diabetics than in normals respectively.
The above results indicated the possibility of the inhibition of postsecretory reabsorption of urate in the distal tubule.
