Abstract
Effects of dietary sodium and potassium on serum uric acid concentration (S-UA) and urinary uric acid excretion (UUA) in Japanese young women were studied in this paper.
Subjects (n=4, female, l9yrs) were fed w ith low sodium (Na), potassium (K) diet for four days, thereafter fed with relatively higher Na, K diet for successive four days. S-UA was determined at first, fourth and eighth experimental days. UUA and urinary electrolytes excretion were measured throughout experiment.
S-UA was decreased, while urine volume (UV), urinary Na (UNa), K (UK) excretion, UUA and urinary creatinine excretion (UCr) were increased, accompanied with the increase in dietary electrolytes intake.
Urinary uric acid concentration was significantly correlated to urinary creatinine concentration (r=0.88), K concentration (r=0.71), (Na+K) concentration (r=0.49) and Na/K ratio (r=-0.43).
Urinary uric acid excretion was correlated to UUA/UCr(r=0.59), UCr (r=0.56) and UK (r=0.45).
These results sugge s ted that uric acid metabolism was influenced by dietary electrolytes levels. And it was also suggested that renal uric acid handling was partly correlated to urinary sodium and potassium excretions. A possible roles of electrolytes on dietary treatment for hyperuricemia were discussed.
