副甲状腺腺腫と腎癌を合併した原発性痛風の一症例

天野 利男; 振津 琢磨; 伊藤 秀彦; 鈴木 興康; 花房 俊昭; 松沢 佑次; 河野 典夫; 森脇 要; 野中 共平; 垂井 清一郎; 岡 聖次; 園田 孝夫

doi:10.14867/gnam1977.8.2_168

Effect of Parathyroid Function on the Uric Acid Metabolism in a Case of Primary Gout Associated with Parathyroid Adenoma and Renal Cell Carcinoma

Toshio AMANO, Takuma FURITSU, Hidehiko ITOH, Koyasu SUZUKI, Toshiaki HANAFUSA, Yuji MATSUZAWA, Norio KONO, Kaname MORIWAKI, Kyohei NONAKA, Seiichiro TARUI, Seiji OKA, Takao SONODA

Author information

Toshio AMANO
1) Second Department of Internal Medicine, Osaka University Medical School
Takuma FURITSU
1) Second Department of Internal Medicine, Osaka University Medical School
Hidehiko ITOH
1) Second Department of Internal Medicine, Osaka University Medical School
Koyasu SUZUKI
1) Second Department of Internal Medicine, Osaka University Medical School
Toshiaki HANAFUSA
1) Second Department of Internal Medicine, Osaka University Medical School
Yuji MATSUZAWA
1) Second Department of Internal Medicine, Osaka University Medical School
Norio KONO
1) Second Department of Internal Medicine, Osaka University Medical School
Kaname MORIWAKI
1) Second Department of Internal Medicine, Osaka University Medical School
Kyohei NONAKA
1) Second Department of Internal Medicine, Osaka University Medical School
Seiichiro TARUI
1) Second Department of Internal Medicine, Osaka University Medical School
Seiji OKA
2) Department of, Urology, Osaka University Medical School
Takao SONODA
2) Department of, Urology, Osaka University Medical School

JOURNAL FREE ACCESS

1984 Volume 8 Issue 2 Pages 168-172

DOI https://doi.org/10.14867/gnam1977.8.2_168

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Abstract

In order to elucidate the influence of parathyroid function on uric acid metabolism, a case of primary gout with parathyroid adenoma was studied before and after adenectomy. The serum calcium level was 5.13±0.15(mean±SE)rnEq/l and serurn 1,25(OH)₂D was 71.5pg/ml(normal: 24.9-65.5) before adenectomy. After the operation the serum calcium and 1,25(OH)₂D levels decreased significantly to 4.35±0.12mEq/l and 18.0 pg/ml, respectively. Although the serum urate remained almost unchanged before and after the operation, the ratio of urate to creatinine clearance increased considerably from 4.93±0.75% to 6.80±0.74%. These data suggest that parathyroid function such as regulation of serum calcium and 1,25 (OH)₂D might influence uric acid metabolism.

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