Abstract
We investigated 15 patients with gout and hyperuricemia (13 with hepatic disturbances,2 with eruption,1 with aplastic anemia and 1 with a complication of hepatic disturbance and eruption), who developed these side effects while being treated with allopurinol, and 19 patients given allopurinol who did not show side - effects (control group). There was no significant difference between the side - effect and control groups in mean duration of treatment (57.3 months) and mean dose (197mg/day). In the lymphocyte stimulation test,3 of 5 positive cases treated with allopurinol and 3 of 4 positive cases given oxipurinol had hepatic disturbances, which were regarded as side - effects. These hepatic disturbances suggest delayed allergic reaction to these drugs. No significant differences in the serum allopurinol and oxipurinol concentrations were observed between the side - effect and control groups. However, the serum oxipurinol concentration was higher in patients with low Ccr who had eruption and aplastic anemia as side - effects.
