Abstract
To elucidate the significance of uric acid in toxemia and pregnancy-induced hypertension (PIH), the relationship between uric acid and clinical parameters was investigated in patients with toxemia and PIH in our hospital. Ninety-three toxemia patients (included 45PIH patients) were examined. In toxemia, factors associate with birth weight were delivery week (r=0.872, p<0.0001), BUN (r=-0.427, p=0.0001), Cr (r=-0.324, p=0.0043), uric acid (r=-0.311, p=0.0072), LDH (r=-0.506, p<0.0001), Hb (r=-0.305, p=0.006), SBP (r=-0.450, p<0.0001), and DBP (r=-0.340, p=0.0007) by univariate analysis. Factors associated with uric acid were BUN (r=0.577, p<0.0001), Cr (r=0.627, p<0.0001), LDH (r=0.388, p=0.0006), platelet (r=-0.245, p=0.0363), delivery week (r=-0.244, p=0.0368), and birth weight (r=-0.311, p=0.0072). There was a correlation between LDH and uric acid in toxemia (r=0.388, p=0.0006). On multiple regression analysis, only LDH was associated with birth weight in both toxemia and PIH. It seems that increased LDH in toxemia and PIH reflects endothelial cell injury rather than simple liver damage. Some common humoral factors may contribute to the correlation between LDH and uric acid through endothelial cell injury.
