Abstracts of the General Sessions of the Japanese Society for Dental Materials and Devices
45th General Session of the Japanese Society for Dental Materials and Devices
Session ID : P-13
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Host: The Japanese Society for Dental Materials and Devices

Gene profiling of human mesenchymal stem cells cultured in osteogenic differentiation medium by DNA microarray
*Masayuki Taira, Kaori Sasaki, Setsuo Saitoh, Yoshima Araki
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Abstract

We cultured human mesenchymal stem cells in osteogenic differentiation medium for 2 weeks, and conducted its gene profiling by DNA microarray. 1368 genes were down-regulated, but 2516 genes were up-regulated. Characteristically, osteogenic-differentiation-related genes such as those of osteonectin, osteopontin, BSP and BMP10 and collagen type 1 and 4 genes were up-regulated, while Cyclin A2 gene was down-regulated. Many genes were identified, but their function is not well known. Future studies are highly expected.

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© 2005 by The Japanese Society for Dental Materials and Devices
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