Methyl methacrylate increases GSTa1 promoter activity

服部 修明; 鈴木 崇弘; 神野 悟史; 桶屋 洋之; 石川 温子; 近藤 千裕; 林 達秀; 伊藤 正満; 金森 孝雄; 河合 逹志; 野口 俊英

doi:10.14832/gsjsdmd.2007f.0.13.0

50th General Session of the Japanese Society for Dental Materials and Devices in conjunction with International Dental Materials Congress 2007

Session ID : PS-05

DOI https://doi.org/10.14832/gsjsdmd.2007f.0.13.0

Conference information

Host: The Japanese Society for Dental Materials and Devices

Poster Presentation Competition

Methyl methacrylate increases glutathion S-transferase alpha 1 promoter activity

*Nobuaki Hattori, Takahiro Suzuki, Satoshi Jinno, Hiroyuki Okeya, Atsuko Ishikawa, Chihiro Kondo, Tatsuhide Hayashi, Masamitsu Ito, Takao Kanamori, Tatsushi Kawai, Toshihide Noguchi

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Keywords: methyl methacrylate, luciferase, glutathion S-transferase

CONFERENCE PROCEEDINGS FREE ACCESS

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Abstract

Methyl methacrylate (MMA) has been a useful material in dentistry and medicine, because of its excellent formability and operability. We have already found out that the toxin response genes such as glutathione S-transferases (GSTs) and NAD(P)H:quinone oxidoreductase 1 (NQO1) were up-regulated after exposure to MMA. In this study, we aimed to establish a new system to screen for MMA and other dental materials.
This system may be useful as a new screening method for other dental material developments.

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