Abstract
Collagen sponges were immersed five times alternately in a phosphate solution and a calcium solution so that precipitates covered the sponge surface. SEM/EPMA, TF-XRD and FTIR confirmed that the flower-shaped precipitates consisted of hydroxyapatite. The apatite-covered collagen sponge was 5 ton pressed, and its capability of osteogenic differentiation of osteoblast SaOS-2 was confirmed.