Drug delivery by sensing its concentration

Abstract

Carrier materials with sensor for drug concentration hold great promise as smart delivery systems for drugs which have strong side effects, such as anticancer agents and bactericides. However, any carriers sensing drug concentration have not been turned to practical use. We found that the phosphopullulan and CPC complex changed their interaction at critical micelle concentration of CPC. It was also revealed that this phenomennon strongly related the bactericidal effects of the complex.