Plasma amyloid ϐ 40/42 ratio and its characteristics

Abstract

Amyloid-β (Aβ) is formed by the cleavage of amyloid precursor protein (APP) and is characterized by the deposition of Aβ in the brain. A high plasma Aβ40/42 ratio is associated with an increased incidence of dementia. In the present study, we analyzed the effect of aging markers on Aβ40/42 from the data of an anti-aging medical check-up conducted in 2019. The subjects included 21 university faculty and staff (FS; 49.3 ± 12.9 years) and 36 independent elderly (Yurin elderly, YE; 79.3 ± 6.4 years) living in the Yurin area of Kyoto, Japan. Statistical analysis was performed using stepwise multiple regression analysis for a total of 13 items, including gender, age, BMI and anti-aging medical check-up items (muscle age, neural age, bone age, blood vessel age, hormone age, glycative stress, oxidative stress, immune stress, physical and mental stress and lifestyle) as independent variables and Aβ40/42 as a dependent variable. For FS, the dependent variable Y (Aβ40/42) was expressed with the equation "Y = −0.131 X1(lifestyle score) + 19.7", where poor lifestyle was a risk factor for elevated Aβ40/42. Neural age was a risk factor for YE, while blood vessel age and glycative stress were risk factors to analyze all subjects for elevated Aβ40/42. We can conclude that neural age, blood vessel age, glycative stress and poor lifestyle may affect the plasma Aβ40/42 ratio and may be risk factors for exacerbating dementia.