Abstract
Purpose: An open-level study with no control was conducted to confirm the changes in subjective and objective symptoms and safety of a food test product (INJUV) containing a rooster comb enzymatic degradation product that contains low molecular weight hyaluronic acid (HA) as a major component.
Methods: From 25 healthy subjects who were aware of dry or eye fatigue, 12 subjects with severe symptoms (male: 6, female: 6, age: 37.8 ± 10.1 years) were selected as subjects. The subjects orally ingested INJUV for 4 weeks, and eye examinations and questionnaires were conducted before and after ingestion, and the results were compared.
Results: Subjective symptoms that improved significantly were "eye dryness," "eye pain," "eye fatigue," and "eyelid heaviness." The nine items that improved significantly in the Anti-Aging QOL Common Questionnaire were "eye fatigue," "blurred vision," "eye pain," "stiff shoulders," "muscle pain/stiffness," "lethargy," "skin problems," "headache," and "dizziness." Tear layer breakdown time improved from 3.6 seconds to 5.5 seconds (p < 0.05), intraocular pressure (IOP) decreased from 13.0 mmHg to 11.7 mmHg (p < 0.01), and diastolic blood pressure decreased from 73.3 mmHg to 68.9 mmHg (p < 0.05). No adverse events were observed during the study period.
Conclusion: Oral intake of INJUV was shown to be safe and improve ocular symptoms, quality of life and ocular surface, as well as lower IOP and diastolic blood pressure.
