Abstract
Background. Solitary squamous cell and glandular mixed papilloma (mixed papilloma) is a histological subtype of papilloma, a rare, benign pulmonary epithelial tumor reported to undergo occasional malignant transformation. We herein present two surgical cases of mixed papilloma. Case Presentation. Case 1: A 49-year-old male was found to have a 28-mm nodule in right S8 with pleural indentation and spicule formation on chest CT. FDG-PET indicated accumulation with SUV 14.8, and the serum CEA level was 5.2 ng/ml. The preoperative pathological diagnosis was well differentiated squamous cell carcinoma based on the findings of a bronchoscopic biopsy. Right lower lobectomy and lymph node dissection were performed. The postoperative pathological examination revealed features of mixed papilloma. Case 2: A 72-year-old male presented with obstructive pneumonia. A bronchoscopic examination disclosed a polypoid tumor obstructing the B6 bronchus, and squamous cell carcinoma was detected in a biopsy specimen. The serum SCC level was 1.6 ng/ml. Left S6 segmentectomy with B6 wedge resection and lymph node dissection was performed. The postoperative pathological examination revealed mixed papilloma with stage 0 squamous cell carcinoma protruding into the internal lumen of the B6 bronchus.
