2016 Volume 56 Issue 3 Pages 227-231
Background. Granulocyte-colony-stimulating factor (G-CSF)-producing lung cancer is associated with a poor prognosis. Case. Case 1: A 68-year-old man was admitted to our hospital due to bloody sputum and arthralgia in his right shoulder. A large mass was identified in his right upper lobe. It was diagnosed as lung cancer (poorly-differentiated non-small cell, stage IV) by CT-guided needle lung biopsy. Although he received systemic chemotherapy, the disease progression was not controllable. He died 3 months after the diagnosis. Case 2: A 64-year-old man presented with an invasive lesion in the right lower lobe. It was diagnosed as lung cancer (adenocarcinoma, stage IIB). Although partial pneumonectomy and lymph-adenectomy were performed, the postoperative pathology showed vessel invasion of the chest wall. Despite the administration of systemic chemotherapy, the patient's the disease progression was not controllable. He died 7 months after the diagnosis. Serum examinations revealed that both cases had leukocytosis and a high concentration of G-CSF. In addition, the tumor cells were positively stained with anti-recombinant human G-CSF monoclonal antibody. Conclusion. Further investigation is therefore necessary to elucidate the prognosis of G-CSF producing lung cancer.
