A case of ovarial adenocarcinoma accompanied by remarkably elevated amylase and alkaline phosphatase activities in serum, pleural fluid, ascites and urine.a peculiar amylase isoen zyme and Regan isoenzyme producing ovarial adenocarcinoma.

Abstract

A 47 years old female was admitted with complain of dyspnea April 4, 1974. One month prior to the admission, she had a abdominal pain and was told that she might have ovarial tumor.
On admission the patient had right pleural fluid, ascites and abdominal tumor. Amylase activities (Somogyi unit) were 1650u. in serum, 8000u. in ascites, 5000u. in pleural fluid, and 5700u. in urine. Al-P activities (K-A unit) were 27. u. in serum, 238u. in ascites and 160u. in pleural fluid.
Ovarial carcinoma was suspected and removed on May 30, '74. Amylase was 95000u. and Al-P was 287u. in 10% homogenates of tumor tissues. Zymograms proved the existence of a peculiar amylase isoenzymes different from those originated from the pancreas and salivary glands and also the existence of Regan type heatstable Al-P isoenzymes. After the operation, these isoenzymes disappeared rapidly.