Experimental Lung Cancer produced in Dogs by intrabronchial Application of 20-methylcholanthrene

part 1. It's techniques and characteristics of induced tumors

Abstract

Lung cancer was induced in seven out of ten adult Mongrel dogs by weekly application of 100mg. 20-methylcholanthrene to the right lower lobe bronchus. 20-MC was administered during the period two years and eleven months to three years and ten months, total dosages administered ranging from 12.4 to 19.4g. The tumors were nodular with well defined borders in six cases and infiltrative with ill-defined borders in one. Metastases were seen in the lymphodes of. tracheal bifurcation and paratracheal regions in all cases. Histologic examination revealed squamous cell carcinoma in two, adenocarcinoma in three and adenoacanthoma in two.