Abstract
In an attempt to clarify differences between local and systemic immune response, regional lymphnode cells (RLNs) and peipheral blood lymphocytes (PBLs) obtained from 19 patients with lung cancer were tested for PHA stimulation, T cell population, T cell subpopulation bearing IgG-Fc receptor.
PHA response rate of non-metastatic RLNCs was approximately two times higher than that seen with PBLs in stage I patients without any pre-operative therapy. With more advanced disease it becAme low, and it was less than half of that with PBLs when the nodes had been invaded with the tumor cells.
In relevant to the location of lymph node the closer to the tumor, the higher the PHA response, and vice versa.
T cell population was found to be lower in RLNCs than in PBLs. It tended to be higher in nodes closer to the tumor.
T cell subpopulation bearing IgG-Fc receptor was higher both in RLNCs and in PBLs than in control samples. No significant difference was observed between each of lymphnodes.
