The Effect of Combination Chemotherapy with Mitomycin C (MMC), Vindesine (VDS) and Cisplatin (CDDP) for Brain Metastasis from Non-Small Cell Lung Cancer

Abstract

The effect of combination chemotherapy (CT) with MMC, VDS and CDDP (MVP-therapy) on brain metastasis from non-small cell lung cancer was studied. Five cases of adenocarcinoma were evaluated. All cases showed neurological improvement after MVP-therapy. In three among five cases experienced PR (more than 50% decrease in size) by brain CT scan. Their survival times were from 6 to 18 months. In order to evaluate strictly the effect of MVP-therapy on brain metastasis from non-small cell lung cancer, a randomized clinical trial of CT alone, CT+ Radiation therapy (RT) and RT alone is recommended.