A Case of Giant Cell Carcinoma of the Lung Associated with Diabetes

Abstract

The patient was a 45-year-old male whose chief complaints were fever, weight loss, and left upper back pain. Deterioration of diabetes was pointed out by a local doctor, and the patient was admitted to our hospital. On chest X-ray film, a mass shadow was found at the left lung apex. This was diagnosed as giant cell carcinoma by needle aspiration biopsy. Fever, leukocytosis, anemia, elevation of serum Al-P and LDH, which are characteristic findings of giant cell carcinoma of the lung, were present before surgery. In addition, blood sugar was so high that 30 units of intermittent insulin and 40 units of rapid insulin per day were required. After resection of the tumor, these conditions improved, and blood sugar was well controlled by 20 units of intermittent insulin. In this case, it seemed that an inflammatory condition due to lung giant cell carcinoma caused deterioration of diabetes.