1993 Volume 33 Issue 2 Pages 233-238
Intraoperative intrapleural hypotonic cisplatin treatment was performed on 9 patients with carcinomatous pleuritis found at thoracotomy and 10 patients with potentialrisk of recurrence in the pleural space. The treatment procedure was as follows. The entire thorax was exposed to cisplatin (50μg/ml) in distilled water for 10-15 min, which was prewarmed at 37°C. Carcinomatous pleuritis in all 8 patients eligible for assessment of the treatment effect has been controlled for 6 to 29 months. In patients with potential risk of recurrence in the pleural space, the appearance of pleural diseases has not been observed for periods of up to 31 months. As the pleura was destroyed by the treatment, postoperative drainage volume was significantly increased, compared to that of patients without the treatment. However, there were no harmful complications after operation.
