Abstract
Molecular shape of proteins and the formation of the polymeric structures of their self-assembled bodies and the aggregates seriously damage the cell, since, as a typical topics, the abnormal aggregation of the proteins observed in the Parkinson's disease and Alzheimer's disease has suggested causing the neurofibrilary degeneration and the final cell death. We are studying the abnormal brain proteins aggregation in water by small-angle neutron scattering. Here, we demonstrated the structure of UCH-L1 (ubiqutin carboxy-terminal hydrolase L1) concerning the proteasome system in water. The mutant and the polymorphism are closely related to the Parkinsonism.
