Carbonylation Reaction of Aryl Halides on a Polymer Support Using In Situ Generated Carbon Monoxide

Abstract

Palladium-catalyzed carbonylation, which was based on a ligand exchange reaction, efficiently converted immobilized aryl halides to amides under mild reaction conditions using molybdenum hexacarbonyl [Mo(CO)₆] as the carbon monoxide source. The method easily operates without irradiating with microwaves and yields a wide range of highly pure amides after cleaving from the resin. The method could also be applied to the carbonylation of immobilized amines with aryl halides and to construct heterocyclic systems via a carbonylative cyclization.