Synsthesis and Biological Activity of Benzo[b]furan Derivatives with Alkylcarbamoylvinyl Groups

Abstract

Novel lipophilic benzo[b]furan derivatives with alkylcarbamoylvinyl groups were designed based on possible conformers of LTB₄. Introductions of alkylcarbamoylvinyl groups to benzo[b]furan ring were accomplished by Heck reaction and/or Horner–Wadsworth–Emmons reaction. The structure of novel compounds was examined by ¹H-, ¹³H-NMR and MS. Several compounds among these show potent LTB₄ receptor antagonistic activity.