Rapid Oligosaccharide Synthesis Using a Novel Fluorous Tag

Abstract

The Bfp and Hfb groups, a novel fluorous tag, were able to be easily prepared. The Bfp and Hfb groups were readily introduced to carbohydrate, removed in high yield, and were recyclable after cleavage. The use of the fluorous tags made it possible to synthesize rapidly an oligosaccharide by minimal column chromatography purification. Each synthetic intermediate was able to be easily purified only by simple fluorous-organic solvent extraction, and monitored by TLC, NMR, and MS.