Cyclization of Phenyl Benzoate Derivatives with Palladium Reagents

Abstract

Aryl–aryl couplings are very important reactions because they have been utilized as key reactions for the syntheses of various natural products. Recently, we reported an intramolecular cyclization of aryl benzoate derivatives with a novel palladium reagent system. In this report, we examined cyclizations of phenyl benzoate derivatives possesing various substituent patterns, in order to investigate the substituent effects to the reactivity and the regioselectivity. Syntheses of graphislactones, which were isolated from graphis prunicola, were also carried out using the intramolecular cyclization of phenyl benzoate derivatives.