Development of a Novel Sugar Linkage: 6, 6'-Ether-Connected Sugars

Abstract

In 1997, coyolosa was isolated from the Acrocomia mexicana root. It is worth noting that coyolosa, which is a new carbohydrate connected by an ether-linkage, shows a significant effect on the fasting blood glucose level. So far, no studies on the sugar linkage by ether bonding have ever been reported. Thus, we examined a novel synthesis of 6,6'-ether-connected pyranoses. Also, we reconsidered the proposed structure of coyolosa based on the structure–activity relationship (SAR) studies.

Scheme 1