Synthetic Study of Benzo[c]phenanthridine Alkaloid Possessing The Biological Activity

Abstract

In the course of our study, the required beta-tetralones were newly synthesized by the Cross-Methathesis reaction using the Grubbs catalyst. Subsequently, their pinacol borates were derived from beta-tetralones in two steps. In addition, total syntheses of benzo[c]phenanthridine alkaloids, nornitidine, noravicine, norchelerythrine, and norsanguinarine were established by the microwave-assisted thermal electrocyclic reaction of 1-azahexatriene system involving the benzene double bond, followed by oxidation.