Synthetic study of the neuronal cell protecting carbazomadurin A, B

Abstract

The biologically active carbazole alkaloids, carbazomadurin A and B were isolated from microorganism Actinomadura madurae 2808-SV1 by Seto and co-workers in 1997. These were also shown to be a potent neuronal cell protecting substance which exhibits a free radical scavenging activity. We report the synthesis of the highly substituted carbazole alkaloids, carbazomadurin A and B by the construction of the appropriate carbazole framework based on the allene-mediated electrocyclic reaction of the 6-electron system involving the indole 2,3-bond.