1954 Volume 23 Issue 5 Pages 287-291
To research for the effective radical of INAH upon the murine leprosy bacillus, aromatic aldehyde derivatives of INAH shown in Table 1 and hydrazines combined with thiazol or pyrimidin nuclei presented in Table 2, have strong inhibitory effect upon the tubercle bacillus in vitro, were examined. The results are summarized in Fig. 1. The compounds which were recognized to have more inhibitory effect are No. 1 and No. 9. The other derivatives have no effect, and No. 2 and No. 3 appear to accelerate the development of murine lepromas.
From these results, the drugs which are effective upon the tubercle bacillus can not be always expected to be efpieient upon the murine bacillus. The validity of INAH upon the murine bacillus can not be attributed only to the hydrazine radical, because the derivatieves consisting of H2N-NH2 can not always have the inhibitory effect, while some of the compounds combined with besides INAH have this effect. Therefore, isonicotinic acid can not be expected to research for the effective radical upon the murine leprosy.
