STUDIES ON SERUM REACTION IN LEPROSY (The 5th Report)
COMPLEMENT FIXATION TEST WITH MODIFIED ANTIGEN
1955 Volume 24 Issue 6 Pages 364-374
Details
1955 Volume 24 Issue 6 Pages 364-374
The antigen for the complement fixation test devised by Honda and Yoshino (1951) was modified.
A mixture was made in a ratio of 0.2% C. L (1):1% C (10):1% Ch (5). Pure
alcohol was added to make 1cc. This antigen was treated with 0.1% Kaolin and then used for experiment.
Sixty (92.4%) out of 65 lepromatous type, 17 (73.9%) out of 23 macular type, and 19 (86.4%) out of 22 neural type were positive.
Three cases out of 38 syphilitic cases, (7.9%), showed a non-specific positive, while none of 19 tuberculous cases, none of 6 cancer cases, 2 of 10 pregnant cases and none of 40 healthy subjects showed this.
The high ratio found in pregnancy does not seem significant in the diagnosis of leprosy. The reaction was little affectated by therapy for the following 6 months on the contrary. Some cases showed an increased reaction.
