Abstract
The early (1 hour) and terminal (24 hours) reactions of intracutaneously injected hyaluronidase in the healthy people were observed, having the local reactional area and intensity as the objects of measurement. The results obtained are as follows :
1) The condition of spreading presents a moderate individual variation, especially, with those whose tuberculin reaction is changing into positive the variance is remarkable.
2) The spreading of hyaluronidase is weak in the male. and strong in the female. But inn the later case before and and after menstration, the spreading is strong and in other period, weak. As for the relation with ages, it is strong in the juvenile period, and decreasing after years in the puberty and youth and shows no change thenceforth.
3) The spreading of hyaluronidase is variable by the seasons. Generally, it is the lowest in the autumn, increasing from the winter to spring and again decreasing from summer to autumn.
