Abstract
It is a well-known fact that any kind of experimental animals so far tested could not be infected with human leprosy bacilli. Furthermore, every former attempt to sensitize animals to response to leprosy bacilli or their extracts with a definite skin reactivity have also ended without bringing about any successful results.
In this connection, an attempt was made by the present authors to sensitize guinea pigs with leprous nodule tissue or leprosy bacilli isolated from it by the Dharmendra technique. These materials were injected intramuscularly being incorporated into liquid paraffin or into a water in oil emulsion of the Freund type. Despite three repeated trials of the experiment, the object was not attained at last. Some discussion was made concerning the possible cause for this failure.
