Abstract
In order the clarify the role of the reticuloendothelial system in the activation of immu nization in murine leprosy, the reticuloendothelial system was blocked with India ink, BCG inoculated and the suppression of development of leproma studied. It was found that at 90 days, the leproma in the india ink injected animal was somewhat larger than that in the normal control. The inhibitory effect was less in the animal in which BCG was administered after injection of india ink than in the mouse in which BCG alone was in oculated. The leproma was larger in the mouse in which M. avium vaccine was injected after injection of india ink than in the animal in which india ink alone was injected. From these results, it can be seen that the reticuloendothelial system is related to the strength of immunity. (See Fig. 1)
Vaccine prepared from acid-fast bacilli other than BCG which have some pathogenicity in mice as the H37Rv, INAH resistant strain and avian strain have antigen activity for murine leprosy.(See Fig. 2)
